Cytokinetics Announces Data From Phase 1 Study of CK-3773274 at the HFSA 23ʳᵈ Annual Scientific Meeting

Cytokinetics Announces Data From Phase 1 Study of CK-3773274 at the HFSA 23ʳᵈ Annual Scientific Meeting

Data Support Progression Phase Clinical Trial Patients Obstructive Hypertrophic Cardiomyopathy Q4 2019 SOUTH SAN Sept. 16, Incorporated today announced from Phase 1 study of (CK-274) were presented poster session at 23rd Annual Scientific Meeting Philadelphia. The study its primary secondary assess safety tolerability of single oral doses of CK-274, well characterize PK/PD relationship regards cardiac function. These support advancement of into Phase trial patients hypertrophic cardiomyopathy which is Cytokinetics Announces Data begin Q4 is selective cardiac myosin inhibitor, development for potential of hypertrophic cardiomyopathy (HCM).

SOUTH SAN FRANCISCO, Calif. , Aug. 21, 2019 (GLOBE NEWSWIRE) -- MyoKardia, Inc. (Nasdaq: MYOK) today announced that it has dosed the first subjects in a Phase 1 clinical study of MYK-224, a small molecule candidate being developed for the treatment of hypertrophic cardiomyopathy (HCM). HCM is a progressive disease in which the excessive contraction of the heart muscle and reduced ability of the left ventricle to fill can lead to the development of debilitating symptoms and cardiac hcm symptoms dysfunction, ranging from shortness of breath and reduced exercise capacity to heart failure and sudden cardiac arrest. MYK-224 selectively targets cardiac myosin, the heart’s motor protein, with the aim of normalizing contractility and filling. “The initiation of our Phase 1 clinical study of MYK-224 in healthy volunteers allows us to further expand our disease-area leadership in hypertrophic cardiomyopathy,” said June Lee, M. D. , MyoKardia’s Chief Development Officer. “Patients experiencing symptoms of HCM currently lack adequate pharmacologic treatment options.

Durability of Mavacamten's Safety Profile Demonstrated through Nine this Study of Patients with Indicative of Potential Improvements Cardiac Function Favorable on Long-Term Disease Burden PARIS SOUTH SAN FRANCISCO, Aug. 31, MyoKardia Begins Dosing Inc. (Nasdaq: today presented positive data company’s PIONEER open-label (OLE) study of mavacamten treatment of symptomatic, Paris, twelve patients evaluable at 36 weeks. Patients MyoKardia Presents 36-week received once-daily oral of mavacamten individually adjusted target concentrations eliminate obstruction of left outflow tract (LVOT).

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