Paper trail leads to heart valve discoveries: Bioengineers' filter-paper models hint at how valves calcify

Paper trail leads to heart valve discoveries: Bioengineers' filter-paper models hint at how valves calcify

Paper is at heart an experimental device developed Rice University bioengineers heart disease. They are paper-based structures that mimic layered nature aortic tissues that keep flowing through heart one direction only. devices allow engineers detail how diseases slow or stop from functioning. The work Brown School team, shows that collagen appears have a association with calcification when Paper trail leads is found outside its domain. Valves hardened calcium deposits are less and lose their ability seal heart's chambers. tissues make a lot excess type 1 collagen," Rice bioengineer Jane Grande-Allen.

Paper is at the heart of an experimental device to study heart disease, researchers report. Researchers are using paper-based structures that mimic the layered nature of aortic valves, the tough, flexible tissues that keep blood flowing through the heart in one direction only. The devices allow the engineers to study in detail how calcifying diseases slow or stop hearts from functioning. The research shows that collagen 1, a natural protein and a component of the valves’ fibrous extracellular matrix, appears to have a strong association calcific aortic stenosis with calcification when it is found outside its usual domain. Valves that calcium deposits harden are less flexible and lose their ability to seal the heart’s chambers. “When tissues make a lot of excess type 1 collagen, it’s called fibrosis,” says Jane Grande-Allen, a professor of bioengineering and the chair of the bioengineering department at Rice University who directed the study with graduate student and lead author Madeline Monroe. “Fibrosis can happen in many types of tissues and it accompanies calcific aortic valve disease (CAVD).

Aortic stenosis is the obstruction blood flow across the valve. Paper device shows Aortic Fast Five Quiz: stenosis several etiologies, calcific (resulting degenerative changes).

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